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We relied on friends and their connections for the cast and crew, which is necessary for a micro-budget film like ours. How did you choose the cast and the crew of your film? So I'd say it is really the other way around. I wrote the script myself, but I did keep in mind as I was writing it, how I'd want to shoot it, and that influenced the script quite a bit. It allowed me to make something that splits the line between documentary and fiction.ĭid you choose a certain directing style for making your film based on the script? It gives everything you make a sense of reality to it, which was perfect for making an autobiographical story. The ability to create characters and stories we care about, and accent that with immediate emotional responses beautiful or horrific images gives us, leads to a kind of poetic synthesis of the best art has to offer. What makes cinema stand out more than the arts for you?įor me, cinema provides both the empathetic connection of literature, with the simple beauty of images. Making a film on a low budget requires so many different skills, it's not just questions of aesthetics, the seemingly boring work of budgeting and logistics end up being essential as well.
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I'd say I'm happy I did that instead of film school because I believe it led to a more well-rounded education. I went to a liberal art school, so I don't have direct experience with film school. It's always been my favorite medium of art, and it was just a matter of pulling together the resources to get it done.ĭo you believe in film schools or does making a film teach you more than film school? Once I knew I was working on a shortened timeline, I knew I had to make something I could be proud of with my time left, and cinema was just the obvious way for me to do it. I've been a film buff my whole life, but before being diagnosed with Huntington's, I wasn't sure I'd ever make a film. I've always been interested in so many fields, and cinema gives me a great variety of tasks, from writing to editing to directing.
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All rights reserved.Filmmaking is just such a complex and layered endeavor, it requires so much of you, and I think that is what makes it so engaging for me. We touch only briefly on the creation of multiple animal models for Huntington's disease that have profoundly impacted our understanding of the disease and permitted the development of potential disease-modifying treatments, and end with what is, at the time of writing, the dawn of a new era: the advent of gene-based therapies (gene silencing, gene editing) for Huntington's disease.ĬAG repeat Huntington’s disease gene editing gene silencing genetic modifiers genetics meiotic instability.Ĭopyright © 2017 Elsevier B.V. Important aspects of the clinical genetics and epidemiology of Huntington's disease are discussed, such as the definition of "normal" and "abnormal" numbers of CAG (cytosine-adenine-guanine) repeats in the critical spot within the huntingtin gene, meiotic instability of CAG repeat numbers, common Huntington's disease genetic haplotypes, compound heterozygosity for an abnormal gene, and somatic mosaicism for CAG repeat expansions. In this chapter, we review the evolution of our understanding of the genetic aspects of HD, and the applications of our understanding in the management of Huntington's disease patients and families over the last 150 years.